UK risk watchdog set to ease bank buffers

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Drug shortages delay cancer clinical trials.

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Surging Red Sox win 5th straight

By HOWARD ULMAN

AP Sports Writer

Associated Press Sports

updated 11:04 p.m. ET June 21, 2012

BOSTON (AP) - Down two runs in the eighth inning, Boston's big guns had a chance to produce.

And Daniel Nava, Will Middlebrooks and Ryan Kalish did.

Who?

The trio with a combined 113 games of major league experience before this season teamed for a three-run, eighth-inning rally and the surging Red Sox completed a sweep of the stumbling Miami Marlins, 6-5 on Thursday night.

Boston tied the score on a two-run homer by Middlebrooks, who drove in four runs. Kalish then singled, raced to third on a groundout to first and scored on Nava's go-ahead single up the middle.

"I love to see guys growing and learning and excelling at the same time," manager Bobby Valentine said. "It's, I guess, a perfect combination."

None of the three began the season in the majors.

Middlebrooks got there on May 2 when fellow third baseman Kevin Youkilis went on the disabled list, Nava on May 10 and Kalish last Sunday. Middlebrooks is batting .316 with eight homers and 31 RBIs in 38 games while sharing time with Youkilis.

"It really hasn't been bad" as a part-time player, he said. "I knew that was going to be my role and I just try to accept it."

Nava is hitting.340 in 35 games and Kalish is hitting. 267 in four games. All three have been aggressive on the basepaths.

"When we were called up here we wanted to gain (the club's) trust and let them know that we can come through and help them win," said Middlebrooks, 23. "So it's good to see it happen."

The Red Sox won their fifth straight game and seventh in their last eight as they matched their season-best mark of three games over .500.

Alfredo Aceves pitched a perfect ninth for his 18th save in 21 opportunities. Scott Atchison (2-0) allowed one hit over the seventh and eighth.

The Marlins took a lead in all three games but lost them all as they dropped their fourth straight overall and 13th in their last 15.

"This hurt a lot," Miami manager Ozzie Guillen said. "We've got to come back with a winning attitude. Fight for it. Good fighter fight the fight. Bad fighter throw in the towel."

Miami went ahead 5-3 with two runs in the sixth. Giancarlo Stanton, in a 2-for-31 slump, hit his first homer in 12 games and 15th of the season to make it 4-3. That ended Daisuke Matsuzaka's streak of 14 consecutive outs and brought in lefty Andrew Miller.

He retired the next batter before giving up a single to Greg Dobbs and a run-scoring double to Omar Infante.

Jarrod Saltalamacchia started the winning rally in the eighth with a double off Randy Choate. Edward Mujica (0-3) came in and served up Middlebrooks' long, tying shot.

Then Nava, who had six singles in the last two games, lined a clean single to center.

"It's fun to watch them, especially in a situation like that," Atchison said. "We hit a two-run homer and then we play a little small ball to go ahead and take the game. It's fun to watch. It doesn't matter who's doing it, but it's really fun to watch these guys come up and contribute."

In just his third start of the season since having Tommy John elbow surgery on June 10, 2011, Matsuzaka gave up a leadoff single in the first to Jose Reyes, who went to third on a slow grounder to shortstop Mike Aviles, who got the out at first. Stanton walked and stole second and both runners scored on a single by Dobbs. After Dobbs stole second, he came in on a single by Infante.

Matsuzaka ended the inning by retiring Scott Cousins on a fly ball to center and didn't allow another runner until Stanton homered.

"We jumped up those few runs and still kind of felt a little shaky," Stanton said. "It wasn't like `Hey, we've got this.' And the result ended that way."

Carlos Zambrano gave up one hit through three innings before Boston tied the game with two runs in the fourth and one in the fifth.

"He gets too anxious with people on base," Guillen said.

Zambrano hit the first two batters, Cody Ross and Saltalamacchia, in the fourth. Ross scored on a single by Middlebrooks and Saltalamacchia came in on a sacrifice fly by Aviles.

The Red Sox evened the score at 3 on another RBI single by Middlebrooks, driving in Adrian Gonzalez, who led off the fifth with a walk.

NOTES: The Red Sox are 24-14 since May 11, baseball's third-best record in that span. ... Boston 2B Dustin Pedroia returned to the lineup after missing one game as a precaution when he felt discomfort in his right hand on his last at-bat in Tuesday night's 7-5 win. ... Marlins owner Jeffrey Loria spoke to his struggling team before the game. ... Miami optioned RHP Chris Hatcher to New Orleans and recalled LHP Mike Dunn from the Triple-A team. ... The Red Sox begin a three-game series at home against the Atlanta Braves on Friday night, sending Jon Lester (4-4) to the mound against Jair Jurrjens (0-2). ... Anibal Sanchez (3-5) is scheduled to pitch Friday night for Miami in the opener of a three-game home series against Toronto, which plans to start Ricky Romero (7-1).

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Surging Red Sox win 5th straight

Daniel Nava singled in the go-ahead run to cap a three-run eighth inning and the Red Sox completed a sweep of the stumbling Miami Marlins, 6-5 on Thursday night.

David Banks / Getty Images

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Apple peel compound boosts calorie burning, reduces obesity in mice

Thursday, June 21, 2012

Obesity and its associated problems such as diabetes and fatty liver disease are increasingly common global health concerns. A new study by University of Iowa researchers shows that a natural substance found in apple peel can partially protect mice from obesity and some of its harmful effects.

The findings suggest that the substance known as ursolic acid reduces obesity and its associated health problems by increasing the amount of muscle and brown fat, two tissues recognized for their calorie-burning properties.

The study, which was published June 20 in the journal PLoS ONE, was led by Christopher Adams, M.D., Ph.D., UI associate professor of internal medicine and a Faculty Scholar at the Fraternal Order of Eagles Diabetes Research Center at the UI.

"From previous work, we knew that ursolic acid increases muscle mass and strength in healthy mice, which is important because it might suggest a potential therapy for muscle wasting," Adams says. "In this study, we tested ursolic acid in mice on a high-fat diet -- a mouse model of obesity and metabolic syndrome. Once again, ursolic acid increased skeletal muscle. Interestingly, it also reduced obesity, pre-diabetes and fatty liver disease.

"Since muscle is very good at burning calories, the increased muscle in ursolic acid-treated mice may be sufficient to explain how ursolic acid reduces obesity. However, we were surprised to find that ursolic acid also increased brown fat, a fantastic calorie burner. This increase in brown fat may also help protect against obesity."

Until quite recently, researchers believed that only infants had brown fat, which then disappeared during childhood. However, improved imaging techniques have shown that adults do retain a very small amount of the substance mostly in the neck and between the shoulder blades. Some studies have linked increased levels of brown fat with lower levels of obesity and healthier levels of blood sugar and blood lipid, leading to the suggestion that brown fat may be helpful in preventing obesity and diabetes.

The UI team, which also included Steven Kunkel, Christopher Elmore, Kale Bongers, Scott Ebert, Daniel Fox, Michael Dyle, and Steven Bullard, studied mice on a high-fat diet over a period of several weeks. Half of the animals also received ursolic acid in their high-fat food. Interestingly, mice whose diet included ursolic acid actually ate more food than mice not getting the supplement, and there was no difference in activity between the two groups. Despite this, the ursolic acid-treated mice gained less weight and their blood sugar level remained near normal. Ursolic acid-treated mice also failed to develop obesity-related fatty liver disease, a common and currently untreatable condition that affects about one in five American adults.

Further study showed that ursolic acid consumption increased skeletal muscle, increasing the animals' strength and endurance, and also boosted the amount of brown fat. Because both muscle and brown fat burn calories, the researchers investigated energy expenditure in the mice and showed that ursolic acid-fed mice burned more calories than mice that didn't get the supplement.

"Our study suggests that ursolic acid increases skeletal muscle and brown fat leading to increased calorie burning, which in turn protects against diet-induced obesity, pre-diabetes and fatty liver disease," Adams says. "Brown fat is beneficial and people are trying to figure out ways to increase it. At this point, we don't know how ursolic acid increases brown fat, or if it increases brown fat in healthy mice. And, most importantly, we don't know if ursolic acid will benefit people. Our next step is to determine if ursolic acid can help patients."

###

University of Iowa Health Care: http://www.uihealthcare.com/index.html

Thanks to University of Iowa Health Care for this article.

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HBT: 'Pine tar' Peralta loses after being suspended

Yesterday afternoon MLB handed down an eight-game suspension to Joel Peralta for having pine tar on his glove, but the Rays reliever appealed and was available to pitch last night against the Nationals and the manager who ratted him out to umpires, Davey Johnson.

And sure enough manager Joe Maddon brought Peralta into the sixth inning of a tie game in relief of starter Matt Moore.

Peralta got the first two outs, but then gave up a double to Jesus Flores, intentionally walked Adam LaRoche, and gave up another double to Danny Espinosa that scored two runs. He ended up taking the loss in a 5-2 defeat, falling to 0-3 with a 4.20 ERA on the season.

So the Nationals get the last laugh and take two of three games in the interleague series, although the Rays did win the actual game in which Peralta was ejected Tuesday night. And remarkably Maddon and Johnson managed to avoid throwing any more fire on their public war of words.

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Six-Wheelers Converge on Goodwood

Just the Facts:

• For the first time ever, three historic British six-wheeled Formula 1 racecars will appear together at the 2012 Goodwood Festival of Speed.
• The trio of six-wheelers include the Tyrrell P34, the March 2-4-0 and the Williams FW08B.
• The annual festival runs June 28 to July 1.

GOODWOOD, England ? For the first time ever, three historic British six-wheeled Formula 1 racecars will appear together at the 2012 Goodwood Festival of Speed. The annual festival runs June 28 to July 1.

The trio of six-wheelers includes the Tyrrell P34, the March 2-4-0 and the Williams FW08B.

Ken Tyrrell's radical racecar, the only one of the three to feature four front wheels and actually enter a race, competed in 1976-'77, with Jody Scheckter and Patrick Depailler finishing 1-2 at the 1976 Swedish Grand Prix.

Robin Herd's March Engineering car, tested in 1977, had four wheels in the rear, as did Frank Williams' experimental six-wheeler in 1982, but neither car was ever entered in a race.

A fourth six-wheeler, the Ferrari 312T6, was tested by Niki Lauda and Carlos Reutemann in 1977, but was never entered in competition by the Scuderia.

Six-wheeled cars were effectively banned from F1 in 1983.

Inside Line says: Today it's the Nissan Deltawing, but back in the 70s it was six-wheelers like these that were pushing the limits of racecar engineering.

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What is Supplemental Health Insurance?

Supplemental health insurance, as the name would suggest, provides enhancements to your existing regular health insurance.? It covers expenses and costs which are not covered by your primary insurance.? For example, if a health condition causes you to lose income, or be unable to pay your regular living expenses, supplementary health insurance can kick in.? If you are self-employed, have children, or know that you would be truly unable to pay your bills if you were incapacitated due to illness or injury, you should consider getting supplemental health insurance.

Unlike a regular health insurance policy, supplemental health insurance can actually pay out benefits in cash.? It doesn?t usually prejudice against pre-existing conditions.? A major category of people who need supplemental health insurance are those who are on Medicare, since that program does not provide benefits for long-term health care, including hospice care and nursing homes, and often prescription drugs.

Supplemental health insurance can be very expensive, though it is worth shopping around for the best plan, as there are many companies who offer this kind of coverage (one of the most famous being AFLAC).? These plans provide cash benefits for many situations where regular insurance falls short.? This may include preventative care, emergencies, hospital stays, etc.? There are even condition-specific policies which may? be purchased, such as those which pay out in case of cancer diagnosis, or heart attack, stroke, or other conditions.

The possibility of becoming disabled is very real, for anyone.? But for many individuals and families, disability / even a temporary one ? could devastate finances for years, even decades.? According to AllAboardBenefits.com having any ?kind of supplemental health insurance called disability income protection can help mitigate these difficulties, as it pays out a monthly benefit until the disability is resolved.? Long term care insurance is another kind of supplemental health insurance, kicking in for hospice care, nursing homes, and assisted living care facilities.

In short, there are many kinds of supplemental health insurance which can give you the peace of mind you need, whether or not you ever end up actually activating the coverage.? Make sure you do your comparison shopping to find the best plan(s) for you and your family.

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